A statistical technique called the transmission disequilibrium test (TDT) looks for a genetic relationship between a trait and a genetic marker. It contrasts the frequencies of alleles passed on and not passed on from parents to impacted children. The foundation of TDT is the idea that the parents' allele at a locus that is not involved in the disease should be randomly transferred if the locus is unrelated to the sickness. Finding mutations connected to disease genes linked to complicated disorders can be done with the use of the TDT. The parents' and afflicted people's genotypes are needed. By comparing the frequency of marker alleles transferred from heterozygous parents to the sick offspring with the frequency of marker alleles not transmitted, the TDT circumvents the issue of ethnicity from association.
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