A helpful technique for identifying mutations connected to disease genes is the TDT. The parents' and afflicted people's genotypes are needed. Even in cases when population admixture and subdivision are the origin of the association, the TDT is a reliable test for linkage and association. By comparing the frequency of marker alleles passed from heterozygous parents to the sick offspring with the frequency of marker alleles not transmitted, it circumvents the issue of ethnic from association. One helpful technique for identifying mutations connected to illness genes linked to complex disorders is the transmission disequilibrium test (TDT). The parents' and affected individuals' genotypes are needed for TDT. A subgroup of acute myeloid leukemias and malignant tumors of the lymphoblastic lineage, such as precursor-B and T lymphoblastic leukemia/lymphoma and lymphoid blast crisis of chronic myeloid leukemia, express TdT.
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